NIH study explains why opioid therapy may not always work well for chronic pain

brain scan

Researchers have shown that pain-induced changes in the rat brain?s opioid receptor system may explain the limited effectiveness of opioid therapy in chronic pain and may play a role in the depression that often accompanies it. These findings clearly show the impact of chronic pain on the brain and its relation to depression.

Pain-Induced Changes in the Brain?s Opioid System May Explain the Limited Effectiveness of Opioid Therapy in Chronic Pain

brain scan

Animal research suggests pain-induced changes in the brain?s opioid receptor system may explain the limited effectiveness of opioid therapy in chronic pain; these changes also may play a role in the depression that often accompanies chronic pain.

Ticks and Lyme Disease: Symptoms, Treatment, and Prevention

Lyme disease is on the rise. How can you prevent it? What are the symptoms, and what should you do if you think you or your pet have it?

5 Things To Know About Mind and Body Approaches for Substance Use Disorders

Mind and body approaches, such as mindfulness-based interventions, have shown some success when used along with the treatment of substance abuse and addiction. Mindfulness-based approaches, in part, attempt to decrease the impact of negative mood, which is thought to serve as a trigger for substance use. Mind and body approaches can be part of a comprehensive addiction treatment plan that includes behavioral modifications, and may include pharmaceuticals to decrease cravings, group therapy, or counseling.

Media Advisory: Physician/researcher to give April 23 lecture on reexamining how chronic pain is managed in primary care

Dr. Erin Krebs

Erin E. Krebs, M.D., M.P.H., to deliver NCCIH-hosted lecture – Reframing the Primary Care Management of Chronic Pain – at NIH Monday, April 23 at 11 a.m.

Shoreside Enterprises Issues Voluntary Nationwide Recall of 7K and Poseidon 4500 (Extreme 1000 Mg) Due to Presence of Undeclared Sildenafil and Tadalafil

Shoreside Enterprises, Inc. recalls 7K (Lot specific: Lot #RO) and Poseidon 4500 (Extreme 1000 mg) (Lot specific: Lot #20117BL) to the consumer level. due to undeclared Sildenafil and/or Tadalafil.

Badger Botanicals Recalls Red Suma, Green Suma, Green Hulu 2, And Red Hulu 2 Kratom Supplements Because Of Possible Salmonella Health Risk

Badger Botanicals recalls 250-g pouches of Green Suma, Red Suma, Green Hulu 2, and Red Hulu 2 kratom dietary supplements sold directly to consumers via the company website from January 1st, 2018 to April l 12th, 2018 due to potential Salmonella contamination.

5 Tips for a Healthy Vacation

As you plan your next beach vacation, make sure your trip is a healthy one. Consider these five tips on sun safety, medications, contact lenses, tattoos, and eating well.

'Gluten-Free' Means What It Says

The only way to manage celiac disease is to avoid eating foods containing gluten. Learn how FDA's definition of 'gluten free' on food labels makes that possible.

Next Steps for Research on Probiotics and Microbial-Host Keystone Organisms

Could discoveries about probiotics and the microbiome eventually help us to eat healthier, live longer, and even eliminate some chronic diseases?

Neural Mechanisms of Manual Therapies for Chronic Pain

In this blog post, Dr. Merav Sabri, of NCCIH’s Division of Extramural Research, discusses the scientific basis for manual therapies and their use in treating chronic pain conditions, and also addresses an NCCIH-sponsored symposium about this at ICIMH on May 11, 2018.

How Many Calories? Keep an Eye on the Menu

FDA's final rule on menu labeling gives consumers the information on calories they need to make informed food choices.

Targeting and Developing Your Clinical Research Proposal

Apply for an NCCIH grant for research involving human participants? If you’re attending the ICIMH meeting, plan to attend this Pre-Congress Workshop: ?Honing Your Clinical Research Proposal for NIH and NCCIH Funding Opportunities? (on Tuesday, May 8, at 2 p.m.).

Looking Back, Looking Forward: NCCIH at 20

In this blog post, NCCIH Outreach Program Manager Anita McRae-Williams discusses some milestones in NCCIH history, and calls attention to an upcoming retrospective session at the upcoming International Congress on Integrative Medicine and Health.

Unpacking the New NIH Policies for Research with Human Participants

Scientific disciplines can differ on what elements of a study are necessary to meet the definition of a ?clinical trial.? Some investigators conducting human subjects research may not know that NIH considers their study to be a clinical trial - - a term defined broadly by NIH as ?a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include placebo or other control) to evaluate the effects of those interventions on health-related biom

ICIMH Roundtable To Explore Research on Creative Art Therapies

Many current health challenges such as autism, chronic pain, and Alzheimer?s disease have remained largely intractable. Research suggests that a combination of therapeutic approaches will likely be needed to address these complex conditions. Creative art therapies may have a role to play in these multidisciplinary strategies. 

Symposium To Explore Science of Music, the Brain, and Health

Can music help people feel better? Many of us would like to say, ?Of course it can.? But what does the research say? 

The fact is that rigorous, systematic investigation of the impact of music on health?particularly in the areas of management of chronic pain and treatment of opioid-use disorder?is just beginning. 

Do You Vape? See These Tips on How to Keep E-Liquids Away from Children

Accidentally touching or drinking e-liquids can be dangerous and even deadly for young children. So it?s important to handle and store these products carefully, to teach children to stay away from these products, and to be prepared for emergencies. Consider these tips.

Symposium To Explore "Sixth Sense," Meditation, and Pain

Have you ever thought about what our ?sixth sense? is? Can we feel it and regulate it? Does it impact our health?

How People Appraise a Heat Stimulus Affects How Their Autonomic Nervous Systems Respond To It, Study Finds

Steam being released from a red pot as a hand lifts the cover

Results of new NCCIH research shows how a person perceives and evaluates stimuli involving actual or prospective pain is an important component in the autonomic nervous system?s (ANS) response to such stimuli.